Description

2'-Fluoro-2'-Deoxyadenosine is a chemically modified nucleoside analog, a critical building block in medicinal chemistry and life science research. This compound is valued for its role in the synthesis of oligonucleotides, particularly for antisense and siRNA applications, where the fluorine substitution enhances stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutics and diagnostic tools.

Application

• Antisense Oligonucleotide Synthesis: A key monomer for creating oligonucleotides with improved nuclease resistance and target affinity for therapeutic applications.
• siRNA and RNAi Research: Used in the development of small interfering RNA (siRNA) molecules for gene silencing studies and therapeutic candidates.
• Pharmaceutical Intermediate: Serves as a crucial synthetic precursor in the development of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to enhance stability and specificity in diagnostic assays and imaging.
• Medicinal Chemistry & Drug Discovery: A versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties of new drug entities.

Basic Information

Product Name	2'-Fluoro-2'-Deoxyadenosine
CAS No.	64183-27-3
Molecular Formula	C10H12FN5O3
Molecular Weight	269.23 g/mol
Synonyms	9-[(2R,3R,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-amine; 2'-F-dA; 2'-Fluoro-2'-deoxyadenosine; 2'-F-2'-dA; 2'-Fluorodeoxyadenosine; 2'-F-Adenosine; 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)adenine; 2'-Fluoro-arabinofuranosyladenine
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2'-Deoxyadenosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Individual impurity ≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.