Description

2'-Deoxyadenosine-5'-o-Monophosphorothioate Sodium Salt is a chemically modified nucleotide analog where a non-bridging oxygen atom in the phosphate group is replaced by sulfur, creating a phosphorothioate linkage. This modification is critical for its primary value as a key building block in the synthesis of antisense oligonucleotides and other therapeutic nucleic acids, offering enhanced nuclease resistance and improved pharmacokinetic properties. It is an essential raw material for pharmaceutical R&D, biotechnology companies, and diagnostic manufacturers focused on next-generation genetic medicines and molecular biology research. The compound is supplied as a high-purity solid, meeting the stringent requirements for advanced therapeutic applications.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A fundamental phosphoramidite precursor for creating therapeutic oligonucleotides with a phosphorothioate backbone.
• siRNA and Aptamer Development: Used in the solid-phase synthesis of siRNA strands and nucleic acid aptamers requiring nuclease-stable linkages.
• Pharmaceutical Research: Serves as an active pharmaceutical ingredient (API) intermediate in the development of gene-targeting drugs.
• Molecular Biology Probes: Enables the creation of labeled or modified DNA probes for diagnostic assays and research.
• Biochemical Tool Development: Used in studying enzyme mechanisms, particularly those of nucleases and polymerases.
• Standards and Reference Materials: Provides a high-purity standard for analytical method development and quality control in oligonucleotide manufacturing.

Basic Information

Product Name	2'-Deoxyadenosine-5'-o-Monophosphorothioate Sodium Salt
CAS No.	64145-26-2
Molecular Formula	C10H14N5O5PSNa
Molecular Weight	394.28 g/mol
Synonyms	2'-Deoxyadenosine 5'-(sodium phosphorothioate); dAMP-α-S Sodium Salt; Adenosine-2'-deoxy-5'-monophosphorothioate sodium; 5'-O-Monophosphorothioate-2'-deoxyadenosine sodium salt; dAMPS sodium; Sp-dAMPS sodium; 2'-Deoxy-5'-O-monophosphorothioateadenosine sodium salt; Sodium 2'-deoxyadenosine-5'-O-phosphorothioate
EINECS	Contact for details

Quality Control

Our 2'-Deoxyadenosine-5'-o-Monophosphorothioate Sodium Salt is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality control protocols are designed to support regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg
Bioburden	< 100 CFU/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.