Description

Thienamycin is a naturally occurring, broad-spectrum carbapenem antibiotic and a pivotal β-lactam compound. Its significance lies in its potent antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, including many multi-drug resistant strains. This makes it a critical intermediate and reference standard for pharmaceutical research and development, particularly in the synthesis of novel antibiotics like imipenem. Industries requiring advanced antimicrobial research, such as pharmaceutical manufacturing, academic institutions, and contract research organizations, rely on high-purity Thienamycin for their development programs.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of clinically important carbapenem antibiotics, most notably imipenem.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research & development (R&D) laboratories for method development, validation, and compound identification.
• Biochemical Research: Employed in microbiological and pharmacological studies to investigate mechanisms of antibiotic action, bacterial resistance, and structure-activity relationships (SAR).
• Antibiotic Discovery: Acts as a lead compound in the research and development of new β-lactam antibiotics with improved efficacy and stability profiles.

Basic Information

Product Name	Thienamycin
CAS No.	64090-99-9
Molecular Formula	C11H16N2O4S
Molecular Weight	272.32 g/mol
Synonyms	(5R,6S)-3-[(2-Aminoethyl)thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; Antibiotic MK 0787; N-Acetylthienamycin; N-Formimidoylthienamycin; (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[(2-aminoethyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Thienamycin is produced and handled under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions upon opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.