Description

Diethyl 2-Fluorobenzylphosphonate is a high-purity organophosphorus compound, specifically a fluorinated benzylphosphonate ester. This specialty chemical serves as a versatile and critical building block in advanced organic synthesis, enabling the precise introduction of functionalized phosphonate groups. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing phosphorus-based bioisosteres or prodrug motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, insecticides, and plant growth regulators that leverage its phosphonate functionality.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized phosphonate ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of flame retardants, polymer modifiers, and specialty surfactants due to its organophosphorus structure.
• Horner-Wadsworth-Emmons (HWE) Reaction: Acts as a stable reagent for the olefination of aldehydes and ketones to synthesize fluorinated alkenes, a valuable transformation in medicinal chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of enzyme inhibitors and activity-based probes targeting phosphatases and other phosphorus-metabolizing enzymes.

Basic Information

Product Name	Diethyl 2-Fluorobenzylphosphonate
CAS No.	63909-54-6
Molecular Formula	C11H16FO3P
Molecular Weight	246.21 g/mol
Synonyms	Diethyl (2-Fluorobenzyl)phosphonate; (2-Fluorobenzyl)phosphonic Acid Diethyl Ester; Diethyl (2-Fluorophenylmethyl)phosphonate; Phosphonic Acid, P-[(2-Fluorophenyl)methyl]-, Diethyl Ester; Diethyl 2-Fluorobenzyl Phosphonate; 2-Fluorobenzylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl 2-Fluorobenzylphosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee it meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.