Description

5-Bromo-α-Oxo-1H-Indole-3-Acetyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in providing a versatile, functionalized indole scaffold for constructing complex molecules with precision. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other biologically active heterocyclic compounds.
• Agrochemical Research: Used in the creation of new herbicides, fungicides, and plant growth regulators that leverage the indole core structure.
• Organic Synthesis Reagent: Serves as a versatile precursor for further functionalization via its reactive acid chloride group, enabling amide coupling, esterification, and other transformations.
• Material Science Research: Employed in the development of advanced organic materials, such as organic semiconductors or photoresists, where the bromo and carbonyl groups offer specific electronic properties.
• Bioconjugation Chemistry: The acid chloride functionality can be utilized for labeling biomolecules or creating targeted molecular probes in biochemical research.

Basic Information

Item	Details
Product Name	5-Bromo-α-Oxo-1H-Indole-3-Acetyl Chloride
CAS No.	63843-81-2
Molecular Formula	C11H7BrClNO2
Molecular Weight	300.54 g/mol
Synonyms	5-Bromo-2-oxo-1H-indole-3-acetyl chloride; 5-Bromo-1H-indole-2,3-dione 3-acetyl chloride; 5-Bromo-isatin-3-acetyl chloride; (5-Bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)acetyl chloride; 5-Bromo-3-(chloroacetyl)-1H-indol-2(3H)-one; 5-Bromooxindole-3-acetyl chloride; 5-Bromo-2-oxindole-3-acetic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Bromo-α-Oxo-1H-Indole-3-Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.