Description

O(6)-Methyldeoxyguanosine Triphosphate is a chemically modified nucleotide triphosphate analog, specifically methylated at the O6 position of the guanine base. This modification is critical for studying DNA alkylation damage, repair mechanisms, and mutagenesis, providing researchers with a precise tool to investigate carcinogenic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers focused on oncology, toxicology, and molecular biology.

Application

• Biochemical Research: Used as a substrate to study the activity and kinetics of DNA repair enzymes, such as O6-alkylguanine-DNA alkyltransferase (AGT).
• Mutagenesis Studies: Essential for in vitro studies investigating the mutagenic potential and replication fidelity of O6-methylguanine lesions in DNA.
• Cancer Research: Employed in modeling DNA damage caused by alkylating agents, aiding in the development of novel chemotherapeutic strategies.
• Diagnostic Assay Development: Serves as a key component in enzymatic assays designed to screen for DNA repair deficiencies or to evaluate potential inhibitors of repair proteins.
• Enzyme Substrate Specificity: Used to probe the substrate specificity of polymerases and other nucleic acid-modifying enzymes when encountering damaged nucleotides.

Basic Information

Product Name	O(6)-Methyldeoxyguanosine Triphosphate
CAS No.	63642-16-0
Molecular Formula	C11H18N5O13P3
Molecular Weight	561.21 g/mol
Synonyms	O6-Methyl-dGTP; 2'-Deoxy-O6-methylguanosine-5'-triphosphate; O6-Methyl-2'-deoxyguanosine-5'-triphosphate; O6-Me-dGTP; 2'-Deoxy-O6-methylguanosine triphosphate; dGTP(O6-Me); O6-Methyl-2'-deoxy-GTP
EINECS	Contact for details

Quality Control

Our O(6)-Methyldeoxyguanosine Triphosphate is manufactured under stringent quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed via HPLC and NMR to confirm identity and purity, with residual solvent analysis performed as required. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity	Conforms in standard enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.