Description

O(6)-Methyldeoxyguanylic Acid is a modified nucleotide derivative of deoxyguanosine monophosphate, where a methyl group is specifically attached to the O6 position of the guanine base. This specific structural modification makes it a critical compound for biochemical research, particularly in the study of DNA damage, repair mechanisms, and mutagenesis. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic companies focused on oncology and genetic toxicology.

Application

• Biochemical Research Standard: Used as a reference standard in studies investigating O6-alkylguanine DNA adducts and their role in carcinogenesis.
• DNA Repair Enzyme Studies: Essential substrate for researching the activity and kinetics of DNA repair enzymes like O6-methylguanine-DNA methyltransferase (MGMT).
• Mutagenesis and Toxicology: Employed in in vitro and in vivo models to understand the mutagenic potential of alkylating agents.
• Pharmaceutical Development: Serves as a key intermediate or reference material in the development of chemotherapeutic agents and MGMT inhibitors.
• Diagnostic Assay Development: Used in the calibration and validation of diagnostic kits designed to detect specific DNA lesions.

Basic Information

Product Name	O(6)-Methyldeoxyguanylic Acid
CAS No.	63642-13-7
Molecular Formula	C11H15N5O7P
Molecular Weight	360.24 g/mol
Synonyms	O6-Methyl-2'-deoxyguanosine 5'-monophosphate; O6-MedGp; O6-Methyl-dGMP; 2'-Deoxy-O6-methylguanosine 5'-monophosphate; O6-Methyl-2'-deoxyguanylic Acid; 5'-O-Phosphono-O6-methyl-2'-deoxyguanosine; O6-Methyl-2'-deoxy-GMP
EINECS	Contact for details

Quality Control

Our O(6)-Methyldeoxyguanylic Acid is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.