Description

(+)-(S)-n-Methylsulfonylphenylalanyl Chloride CAS NO 63640-54-0 is a high-purity, chiral amino acid derivative specifically designed as a critical building block in advanced organic synthesis. This compound is essential for the controlled introduction of the (S)-n-methylsulfonylphenylalanyl moiety, enabling precise stereochemistry in target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-mimetic drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a sulfonamide-containing phenylalanine analog, modifying peptide stability and receptor binding properties.
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged molecular probes to study enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric synthesis to construct complex molecules with high enantiomeric purity for medicinal chemistry programs.
• Agrochemical Research: Potential intermediate in the synthesis of chiral, biologically active compounds for crop protection agents.

Basic Information

Product Name	(+)-(S)-n-Methylsulfonylphenylalanyl Chloride
CAS No.	63640-54-0
Molecular Formula	C₁₁H₁₄ClNO₃S
Molecular Weight	275.75 g/mol
Synonyms	(S)-2-[(4-Methylsulfonyl)phenyl]-1-chloro-1-oxo-3-phenylpropane; L-Phenylalanine, 4-(methylsulfonyl)-, 1-chloride; (S)-4-Methanesulfonylphenylalanyl chloride; N-[(S)-1-Chloro-1-oxo-3-phenyl-2-[(4-methylsulfonyl)phenyl]propyl]amide; MS-Phe-Cl; (S)-Methylsulfonylphenylalanine acid chloride
EINECS	Contact for details

Quality Control

Our (+)-(S)-n-Methylsulfonylphenylalanyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and titration for assay purity, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is between -20°C to -10°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.