Description

Zebularine is a potent and stable cytidine analog that functions as a DNA methyltransferase (DNMT) inhibitor. This compound is of significant interest for its role in epigenetic research, enabling the study of DNA methylation patterns and gene expression regulation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, oncology research, and the development of novel therapeutic agents.

Application

• Epigenetics Research: A key tool for studying DNA demethylation and gene reactivation in cellular models.
• Oncology & Cancer Research: Investigated for its potential to reverse aberrant methylation in cancer cells and restore tumor suppressor gene function.
• Biochemical Assay Development: Used as a reference standard and active component in high-throughput screening assays for DNMT activity.
• Pharmaceutical R&D: Serves as a lead compound or intermediate in the development of novel epigenetic therapies.
• Cell Biology Studies: Employed to explore the role of DNA methylation in differentiation, aging, and cellular reprogramming.
• Academic Research: Widely used in university and institutional labs for fundamental research in genetics and molecular biology.

Basic Information

Product Name	Zebularine
CAS No.	63527-47-9
Molecular Formula	C9H12N2O5
Molecular Weight	228.20 g/mol
Synonyms	1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one; 1-(β-D-Ribofuranosyl)dihydropyrimidin-2(1H)-one; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one (obsolete); NSC 309132; DNMT Inhibitor I
EINECS	Contact for details

Quality Control

Our Zebularine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing purity, identity, and all relevant specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.