Description

1 β-D-Arabinofuranosylcytosine 5'-Diphosphate-L-1,2 Dipalmitin is a chemically modified nucleoside lipid conjugate, a sophisticated building block for advanced pharmaceutical and biochemical research. This compound is critical for developing targeted drug delivery systems and novel therapeutic agents, particularly in oncology and gene therapy. It is primarily utilized by research institutions, pharmaceutical R&D departments, and manufacturers of specialty fine chemicals for high-value applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A key synthetic intermediate for constructing ionizable cationic lipids used in mRNA and siRNA delivery systems.
• Prodrug Development: Serves as a lipophilic prodrug moiety for nucleoside analogs like cytarabine (Ara-C), enhancing cellular uptake and bioavailability.
• Anticancer Research: Investigated for its potential to improve the therapeutic index and reduce systemic toxicity of chemotherapeutic agents.
• Bioconjugation & Labeling: Used in the synthesis of labeled probes for studying cellular metabolism and drug tracking.
• Phospholipid Analog Synthesis: Acts as a precursor for novel phospholipids with tailored head groups for membrane studies.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the role of lipid-modified nucleotides in signaling pathways.

Basic Information

Product Name	1 β-D-Arabinofuranosylcytosine 5'-Diphosphate-L-1,2 Dipalmitin
CAS No.	63357-80-2
Molecular Formula	C55H100N3O16P2
Molecular Weight	1120.36 g/mol
Synonyms	Ara-CDP-Dipalmitin; Cytarabine 5'-Diphosphate-1,2-Dipalmitoyl-sn-glycerol; 1-β-D-Arabinofuranosylcytosine 5'-(1,2-dihexadecanoyl-sn-glycero-3-hydrogen phosphate); Cytosine Arabinoside Dipalmitoyl Phosphatide; L-α-1,2-Dipalmitoylphosphatidyl Cytarabine; 5'-Cytarabine Diphosphate Dipalmitin; Ara-CDP-L-α-Dipalmitin
EINECS	Contact for details

Quality Control

Every batch of 1 β-D-Arabinofuranosylcytosine 5'-Diphosphate-L-1,2 Dipalmitin is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC chromatograms and NMR spectra, to verify identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.