Description

(5B)-1,3,12-Trihydroxy-Cholan-24-Oic Acid CAS NO 63266-91-1 is a high-purity, multi-hydroxylated bile acid derivative, serving as a critical intermediate and reference standard in advanced pharmaceutical research and development. Its defined stereochemistry and functional groups make it invaluable for synthesizing novel therapeutic agents and studying metabolic pathways. This compound is primarily sought by research institutions and pharmaceutical companies focused on hepatology, gastroenterology, and metabolic disease treatment.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel bile acid analogs and hepatoprotective drugs.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Research: Tool compound for studying bile acid metabolism, nuclear receptor (e.g., FXR) activation, and cholesterol homeostasis.
• Metabolic Pathway Studies: Used in in vitro and in vivo models to investigate liver function and digestive processes.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development of potential APIs for treating cholestatic liver diseases.

Basic Information

Product Name	(5B)-1,3,12-Trihydroxy-Cholan-24-Oic Acid
CAS No.	63266-91-1
Molecular Formula	C₂₄H₄₀O₅
Molecular Weight	408.57 g/mol
Synonyms	1,3,12-Trihydroxy-5β-cholan-24-oic Acid; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid; Trihydroxycholanic Acid; Cholic Acid (Note: Cholic acid typically refers to the 3α,7α,12α-trihydroxy isomer); 5β-Cholan-24-oic acid-1,3,12-triol; 63266-91-1; 1,3,12-Trihydroxy-5β-cholanic Acid
EINECS	Contact for details

Quality Control

Our (5B)-1,3,12-Trihydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.