Description

N2-Isobutyryl-2'-o-Methyl-Guanosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and pharmaceutical development. This compound is critical for the synthesis and study of oligonucleotides, where it serves as a protected building block to enhance stability and control reactivity. It is primarily utilized by researchers and manufacturers in the fields of antisense therapeutics, diagnostic probe development, and nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for solid-phase synthesis of modified RNA and DNA strands.
• Antisense and siRNA Therapeutics: Used in the development of therapeutic oligonucleotides with improved nuclease resistance and pharmacokinetic properties.
• Diagnostic Probe Design: Incorporation into probes for qPCR, FISH, and other molecular diagnostics to fine-tune hybridization characteristics.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-RNA interactions.
• Bioconjugation and Labeling: Serves as a starting point for attaching reporter molecules or other functional groups to nucleic acids.
• Academic and Industrial R&D: Fundamental research tool in chemistry, biochemistry, and molecular biology laboratories.

Basic Information

Product Name	N2-Isobutyryl-2'-o-Methyl-Guanosine
CAS No.	63264-29-9
Molecular Formula	C16H23N5O6
Molecular Weight	381.39 g/mol
Synonyms	2'-O-Methyl-N2-isobutyrylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-2-(2-methylpropanoylamino)-1H-purin-6-one; N2-Isobutyryl-2'-O-methylguanosine; 2'-O-Me-N2-ibu-G; 2'-O-Methyl-N2-isobutyryl-guanosine; Guanosine, N2-(2-methyl-1-oxopropyl)-2'-O-methyl-; 2'-O-Methyl-N-isobutyrylguanosine
EINECS	Contact for details

Quality Control

Our N2-Isobutyryl-2'-o-Methyl-Guanosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for pharmaceutical and life science research. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.