Description

Demethylblasticidin S is a potent nucleoside antibiotic analog derived from Blasticidin S, a key compound in molecular biology and agricultural research. Its primary value lies in its role as a selective agent in genetic engineering, particularly for plant transformation and eukaryotic cell culture systems. This high-purity biochemical is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and agrochemical sectors who require reliable and consistent performance in selective media.

Application

• Plant Biotechnology & Genetic Engineering: Used as a selective agent in plant transformation protocols, particularly for rice and other monocots, to inhibit the growth of non-transformed cells.
• Eukaryotic Cell Culture Research: Serves as a selection marker in mammalian and other eukaryotic cell lines engineered with resistance genes, such as bsr or BSD.
• Molecular Biology Reagent: A critical component in the preparation of selective media for cloning and stable cell line development.
• Agricultural Research: Studied for its mode of action as a protein synthesis inhibitor and its potential effects on fungal pathogens.
• Pharmaceutical Intermediate: Acts as a key starting material or reference standard in the synthesis and development of novel antimicrobial agents.

Basic Information

Product Name	Demethylblasticidin S
CAS No.	63257-29-4
Molecular Formula	C16H25N7O5
Molecular Weight	395.41 g/mol
Synonyms	N-Demethylblasticidin S; Blasticidin S, N-Demethyl-; 1-(4-Amino-1,2-dihydro-2-oxopyrimidin-1-yl)-4-[[(1S)-3-amino-1-(aminocarbonyl)-3-oxopropyl]amino]-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid; (2S)-2-[[(1S)-1-Carbamoyl-2-[(4R,5R,6S)-4,5,6-trihydroxy-2-(4-imino-2-oxo-1H-pyrimidin-1-yl)cyclohex-2-en-1-yl]aminoethyl]carbamoyl]amino]-3-methylbutanoic acid; Antibiotic BABS 3B; NSC 326226
EINECS	Contact for details

Quality Control

Our Demethylblasticidin S is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Confirmed by microbiological assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.