Description

2'-Deoxycytidine 5'-(Dihydrogen Phosphorothioate) Monosodium Salt is a chemically modified nucleoside building block, specifically a phosphorothioate derivative of deoxycytidine. This modification, where a sulfur atom replaces one of the non-bridging oxygen atoms in the phosphate backbone, is critical for enhancing the stability and biological activity of synthetic oligonucleotides. It is an essential raw material for research and production in antisense oligonucleotide (ASO) therapeutics, siRNA, aptamers, and diagnostic probes. Global pharmaceutical and biotechnology companies rely on this high-purity intermediate to develop advanced genetic medicines targeting a wide range of diseases.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for creating therapeutic ASOs with nuclease resistance.
• siRNA and miRNA Agonist/Antagonist Production: Used in the solid-phase synthesis of siRNA strands to modulate gene expression.
• Diagnostic Probe and Aptamer Development: Incorporated into nucleic acid probes for enhanced stability in diagnostic assays and sensor applications.
• Research Grade Oligonucleotide Synthesis: Serves as a building block for academic and industrial research into novel oligonucleotide sequences and functions.
• Phosphorothioate Backbone Modification: Essential for introducing sulfur modifications that alter the pharmacokinetic and pharmacodynamic properties of therapeutic nucleic acids.
• GMP-grade Active Pharmaceutical Ingredient (API) Intermediate: A critical starting material in the cGMP manufacturing pipeline for oligonucleotide-based drugs.

Basic Information

Product Name	2'-Deoxycytidine 5'-(Dihydrogen Phosphorothioate) Monosodium Salt
CAS No.	63225-09-2
Molecular Formula	C9H13N3O6PSNa
Molecular Weight	345.25 g/mol
Synonyms	5'-O-Phosphorothioate-2'-deoxycytidine Monosodium Salt; 2'-Deoxycytidine 5'-Monophosphorothioate Sodium Salt; dCMP(S) Sodium Salt; Deoxycytidine Monophosphorothioate Sodium Salt; 2'-Deoxycytidylyl-5' Phosphorothioate Sodium Salt; Sodium 2'-Deoxycytidine-5'-O-phosphorothioate; dCMP-α-S Sodium Salt
EINECS	Contact for details

Quality Control

Our 2'-Deoxycytidine 5'-(Dihydrogen Phosphorothioate) Monosodium Salt is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, NMR spectroscopy, and mass spectrometry. We provide full traceability and detailed Certificates of Analysis (COA) for every lot. Specifications can be aligned with research-grade or cGMP guidelines based on customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, seal under argon or nitrogen. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.