Description

Ribavirin 5'-Diphosphate is the biologically active diphosphate metabolite of the broad-spectrum antiviral nucleoside analog, Ribavirin. This compound is critical for research into the precise mechanism of action of Ribavirin, which involves inhibition of viral RNA-dependent RNA polymerases and modulation of host immune responses. It is an essential biochemical tool for virologists, pharmaceutical researchers, and biochemists studying antiviral therapies, nucleotide metabolism, and enzyme kinetics.

Application

• Antiviral Mechanism of Action Studies: Used as a key reference standard to investigate the inhibition of viral RNA polymerases from pathogens like Hepatitis C Virus (HCV), Respiratory Syncytial Virus (RSV), and others.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic assays to study inosine monophosphate dehydrogenase (IMPDH) and other nucleotide-metabolizing enzymes.
• Pharmaceutical Development: Employed in the research and development of new antiviral agents and in metabolic pathway analysis for drug discovery programs.
• Metabolite Analysis: Acts as a critical analytical standard in LC-MS, HPLC, and other chromatographic methods for quantifying Ribavirin and its metabolites in pharmacokinetic studies.
• Cell Culture & Virology: Used in controlled experiments to understand intracellular conversion and activity of nucleoside analog drugs.

Basic Information

Product Name	Ribavirin 5'-Diphosphate
CAS No.	63142-70-1
Molecular Formula	C8H15N4O14P2
Molecular Weight	453.17 g/mol
Synonyms	1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide 5'-diphosphate; Ribavirin-DP; Ribavirin diphosphate; RVDP; Ribavirin 5'-pyrophosphate; 5'-Diphosphorylribavirin; Virazole 5'-diphosphate
EINECS	Contact for details

Quality Control

Our Ribavirin 5'-Diphosphate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to ensure it meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.