Description

26,27-Dinorcholest-5-En-23-Yn-3β-Ol is a high-purity, synthetic sterol derivative with a modified cholestane backbone, featuring a terminal alkyne group at the C-23 position. This unique molecular structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in steroid-based drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel steroid-based drugs and bioactive molecules.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization due to its reactive alkyne functionality.
• Bioconjugation & Probe Synthesis: The terminal alkyne group enables efficient conjugation via click chemistry (e.g., CuAAC) for creating labeled probes, imaging agents, or targeted drug conjugates.
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic & Institutional Research: Employed in biochemical and pharmacological studies investigating sterol metabolism and receptor interactions.

Basic Information

Product Name	26,27-Dinorcholest-5-En-23-Yn-3β-Ol
CAS No.	63015-89-4
Molecular Formula	C₂₅H₃₈O
Molecular Weight	354.57 g/mol
Synonyms	23-Ethynyl-3β-hydroxy-26,27-dinorcholest-5-ene; 3β-Hydroxy-26,27-dinorcholest-5-en-23-yne; 26,27-Bisnorcholest-5-en-23-yn-3β-ol; 23-Ethynyl-26,27-dinorcholest-5-en-3β-ol; (3β)-23-Ethynyl-26,27-dinorcholest-5-en-3-ol; Sterol Alkyne Derivative; Cholestane Alkyne Intermediate
EINECS	Contact for details

Quality Control

Our 26,27-Dinorcholest-5-En-23-Yn-3β-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data on purity, impurities, and physical characteristics. Our quality commitment supports cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.