Description

5-Bromobenzo[B]Furan-2-Carbonyl Chloride is a high-value, reactive organic intermediate characterized by its brominated benzofuran core and acid chloride functional group. This compound matters as a critical building block in synthetic organic chemistry, enabling the efficient introduction of the 5-bromobenzofuran-2-carbonyl moiety into more complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to develop novel fungicides, herbicides, and insecticides with the benzofuran scaffold for enhanced efficacy.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic semiconductors, luminescent materials, and polymers.
• Chemical Biology & Proteomics: Employed as a coupling reagent or labeling agent for modifying peptides, proteins, or other biomolecules.
• Academic & Contract Research: Essential for methodological development and exploring new chemical spaces in university and CRO laboratories.
• Custom Synthesis & Scale-Up: A vital starting material for contract manufacturing organizations (CMOs) producing custom intermediates for client projects.

Basic Information

Item	Detail
Product Name	5-Bromobenzo[B]Furan-2-Carbonyl Chloride
CAS No.	62878-96-0
Molecular Formula	C9H4BrClO2
Molecular Weight	259.48 g/mol
Synonyms	5-Bromobenzofuran-2-carbonyl chloride; 2-Benzofurancarbonyl chloride, 5-bromo-; 5-Bromo-2-benzofurancarboxylic acid chloride; 5-Bromobenzofuran-2-carboxylic acid chloride; 5-Bromo-1-benzofuran-2-carbonyl chloride; 5-Bromobenzo[b]furan-2-carboxylic acid chloride; 5-Bromo-2-carboxybenzofuran chloride; 62878-96-0
EINECS	Contact for details

Quality Control

Our 5-Bromobenzo[B]Furan-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from strong acids and organic solvents. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.