Description

2',3'-Dialdehyde Guanosine Diphosphate is a chemically modified nucleotide derivative, specifically a dialdehyde analog of guanosine diphosphate. This compound is a critical intermediate and research tool in the fields of biochemistry and molecular biology, valued for its reactive aldehyde groups which enable specific cross-linking and conjugation chemistries. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers for probing enzyme mechanisms, studying nucleic acid-protein interactions, and developing novel bioconjugates.

Application

• Biochemical Research: As a substrate analog for studying the mechanism of GTP-binding proteins (G-proteins) and nucleotide-dependent enzymes.
• Bioconjugation & Labeling: The reactive aldehyde groups facilitate covalent attachment to proteins, peptides, or solid supports for creating affinity probes or diagnostic reagents.
• Enzyme Inhibition Studies: Used to investigate and develop inhibitors for enzymes that utilize GDP/GTP as cofactors or substrates.
• Nucleic Acid Chemistry: Serves as a specialized building block for synthesizing modified oligonucleotides with unique reactive handles.
• Structural Biology: A tool for X-ray crystallography or NMR studies to elucidate the structure and dynamics of nucleotide-binding sites.
• Diagnostic Development: Potential use in the development of high-sensitivity assay systems, such as ELISA or lateral flow assays, through its conjugation capabilities.

Basic Information

Product Name	2',3'-Dialdehyde Guanosine Diphosphate
CAS No.	62695-32-3
Molecular Formula	C10H13N5O12P2
Molecular Weight	481.18 g/mol
Synonyms	Periodate-Oxidized Guanosine Diphosphate; oGDP; GDP Dialdehyde; 2',3'-Di-GDP; Guanosine 5'-(trihydrogen diphosphate), 2',3'-dialdehyde; Oxidized Guanosine Diphosphate; GDP-2',3'-dialdehyde
EINECS	Contact for details

Quality Control

Our 2',3'-Dialdehyde Guanosine Diphosphate is manufactured under stringent quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.