Description

5,6-Dihydro-5-Azacytidine is a modified nucleoside analog of cytidine, where a nitrogen atom replaces carbon at the 5-position of the pyrimidine ring and the 5,6-bond is saturated. This compound is a key intermediate and research chemical in the development of novel epigenetic therapies and nucleic acid chemistry. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on oncology and molecular biology. The product is supplied with stringent quality control to ensure consistency for sensitive biochemical applications.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of DNA methyltransferase (DNMT) inhibitors for epigenetic cancer therapy research.
• Biochemical Tool Compound: Used in laboratory studies to investigate mechanisms of DNA methylation, gene expression, and cellular differentiation.
• Nucleoside Chemistry: Acts as a building block for the synthesis of modified oligonucleotides and other nucleoside analogs with potential therapeutic activity.
• Oncology Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy of demethylating agents.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5,6-Dihydro-5-Azacytidine
CAS No.	62488-57-7
Molecular Formula	C8H13N3O5
Molecular Weight	231.21 g/mol
Synonyms	5,6-Dihydro-5-azacytidine; NSC 264880; 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one; 5-Aza-dihydrocytidine; Dihydro-5-azacytidine; 1-(β-D-Ribofuranosyl)-5,6-dihydro-4-amino-1,3,5-triazin-2(1H)-one; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one, 5,6-dihydro-
EINECS	Contact for details

Quality Control

Our 5,6-Dihydro-5-Azacytidine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically assessed by HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.