Description

8,5'-Cycloadenosine is a unique cyclonucleoside derivative of adenosine, characterized by an intramolecular covalent bond between the sugar and base moieties. This structural modification makes it a valuable reference standard and synthetic intermediate for studying nucleic acid damage, repair mechanisms, and the biological effects of radiation. It is primarily utilized by research institutions and pharmaceutical companies engaged in radiobiology, oncology research, and nucleotide chemistry.

Application

• Biochemical Research: Used as a critical reference standard in the study of radiation-induced DNA damage and the formation of cyclonucleosides.
• Pharmaceutical Development: Serves as a key intermediate or model compound in the synthesis of novel nucleoside analogs for therapeutic applications.
• Analytical Chemistry: Employed as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quantifying DNA lesions.
• Toxicology Studies: Utilized to investigate the mechanisms of action of certain genotoxic agents and to assess cellular repair pathways.
• Academic Research: Fundamental tool in universities and research labs for exploring nucleic acid structure, stability, and chemical biology.

Basic Information

Product Name	8,5'-Cycloadenosine
CAS No.	62475-47-2
Molecular Formula	C10H11N5O4
Molecular Weight	265.23 g/mol
Synonyms	8,5'-Cyclo-2'-deoxyadenosine; 8,5'-cA; 8,5'-Cyclo-dA; 8,5'-Cyclodeoxyadenosine; Adenosine, 8,5'-cyclo-; 8,5'-Cyclo-9-β-D-ribofuranosyladenine; 8,5'-Anhydro-8-hydroxy-2',5'-dideoxyadenosine
EINECS	Contact for details

Quality Control

Our 8,5'-Cycloadenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.