Description

2'-Deoxy-7,8-Dihydro-8-Oxoadenosine is a modified nucleoside derivative, serving as a critical building block and reference standard in advanced biochemical research. Its value lies in its role as a stable analog of oxidized DNA damage products, enabling studies into oxidative stress, DNA repair mechanisms, and mutagenesis. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and academic biochemistry, where precise and high-purity biochemical tools are paramount.

Application

• Biochemical Research: Used as a stable reference standard for the detection and quantification of 8-oxo-dG and related oxidative DNA lesions.
• Pharmaceutical R&D: Serves as a key intermediate or analytical standard in the development of drugs targeting DNA repair pathways and conditions related to oxidative stress.
• Diagnostic Assay Development: Employed in the calibration and validation of diagnostic kits and assays designed to measure oxidative DNA damage biomarkers.
• Toxicology Studies: Utilized to investigate the genotoxic effects of environmental toxins, radiation, and chemotherapeutic agents.
• Academic Research: Fundamental tool for studying the mechanisms of base excision repair (BER) and the biological consequences of endogenous DNA damage.
• Standards Manufacturing: Critical for producing certified reference materials (CRMs) for analytical laboratories and regulatory testing.

Basic Information

Product Name	2'-Deoxy-7,8-Dihydro-8-Oxoadenosine
CAS No.	62471-63-0
Molecular Formula	C10H13N5O4
Molecular Weight	267.24 g/mol
Synonyms	8-Oxo-2'-deoxyadenosine; 8-Oxo-dA; 7,8-Dihydro-8-oxo-2'-deoxyadenosine; 8-Hydroxy-2'-deoxyadenosine; 8-OH-dA; Oxidized Deoxyadenosine; 2'-Deoxy-8-oxoadenosine
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxy-7,8-Dihydro-8-Oxoadenosine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.