Description

1,N(2)-Ethenoguanosine is a chemically modified nucleoside analog, specifically an etheno derivative of guanosine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a DNA adduct formed from the reaction of guanine residues with certain carcinogenic metabolites, such as vinyl chloride. It serves as a critical reference standard and tool compound for researchers in toxicology, analytical chemistry, and molecular biology studying mutagenesis, DNA damage, and repair mechanisms.

Application

• Biochemical Research Standard: Used as a high-purity analytical standard for the quantification and identification of etheno-DNA adducts in biological samples.
• Toxicology Studies: Essential for investigating the mechanisms of carcinogenesis induced by environmental toxins like vinyl chloride and urethane.
• DNA Damage & Repair Research: Employed in studies to understand cellular repair pathways for alkylated and exocyclic DNA lesions.
• Analytical Method Development: Serves as a critical calibrant in advanced chromatographic (HPLC, LC-MS) and spectroscopic methods for adductomics.
• Pharmaceutical Impurity Profiling: Can be used as a reference marker in the quality control of nucleoside-based active pharmaceutical ingredients (APIs).
• Educational & Diagnostic Kits: Incorporated into laboratory kits for teaching advanced concepts in genetic toxicology and for diagnostic assay development.

Basic Information

Product Name	1,N(2)-Ethenoguanosine
CAS No.	62462-38-8
Molecular Formula	C12H13N5O5
Molecular Weight	307.26 g/mol
Synonyms	1,N2-Ethenoguanosine; 1,N²-Etheno-9-β-D-ribofuranosylguanine; 3,9-Dihydro-9-β-D-ribofuranosyl-3H-imidazo[2,1-i]purin-7-one; Etheno-guanosine; 1,N2-ε-Guanosine; 1,N2-ε-Guo; 1,N(2)-ε-Guanosine; Guanine, 1,2-dihydro-2-oxo-1-(β-D-ribofuranosyl)-, cyclic 1,N2-etheno derivative
EINECS	Contact for details

Quality Control

Our 1,N(2)-Ethenoguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (UV, IR, NMR), and residual solvent analysis, to ensure it meets the stringent requirements of research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.