Description

Dimethyl-n-Propylsilylimidazole (CAS NO 62365-35-9) is a specialized organosilicon reagent primarily used as a silylating agent in organic synthesis. This compound is valued for its ability to introduce the dimethyl-n-propylsilyl protecting group, offering a strategic balance between steric bulk and reactivity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise protection of sensitive functional groups, such as alcohols and amines, during multi-step synthetic sequences.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of hydroxyl and amino groups in the production of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced pesticides and herbicides where selective protection is required.
• Peptide Chemistry: Employed as a silylating agent to protect specific amino acid side chains during solid-phase and solution-phase peptide synthesis.
• Natural Product Synthesis: Facilitates the construction of complex natural product scaffolds by protecting sensitive functionalities.
• Material Science Research: Serves as a precursor or modifying agent in the development of silicon-based polymers and advanced hybrid materials.
• Cross-Coupling Reactions: Can be utilized to prepare organosilicon reagents for use in palladium-catalyzed cross-coupling processes.

Basic Information

Product Name	Dimethyl-n-Propylsilylimidazole
CAS No.	62365-35-9
Molecular Formula	C8H16N2Si
Molecular Weight	168.31 g/mol
Synonyms	1-[(Dimethylpropylsilyl)]imidazole; Dimethylpropylsilyl imidazole; N-(Dimethyl-n-propylsilyl)imidazole; DMPSI; 1H-Imidazole, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 1-(Dimethylpropylsilyl)imidazole; (Dimethylpropylsilyl)imidazole
EINECS	Contact for details

Quality Control

Our Dimethyl-n-Propylsilylimidazole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.