Description

Dimethylethylsilylimidazole is a versatile organosilicon reagent primarily used as a silylating agent and protecting group precursor in advanced organic synthesis. Its value lies in its ability to selectively introduce the dimethylethylsilyl (DMES) group, offering a steric and electronic profile distinct from more common silyl groups like TMS or TBDMS. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty materials industries who require precise control over molecular structure during multi-step syntheses. The CAS number for this compound is 62365-34-8.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent for protecting hydroxyl groups during the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Employed in the manufacture of advanced pesticides and herbicides where specific silyl protection strategies are required.
• Peptide Chemistry: Facilitates the protection of sensitive functional groups in the solid-phase and solution-phase synthesis of peptides.
• Nucleoside & Carbohydrate Chemistry: Crucial for the selective derivatization and protection of sugar alcohols and nucleosides in medicinal chemistry projects.
• Material Science Research: Acts as a precursor or surface-modifying agent in the development of silicon-based polymers and advanced hybrid materials.
• Process Chemistry & Scale-up: Valued for its reliability and defined reactivity in pilot plant and manufacturing-scale chemical processes.

Basic Information

Product Name	Dimethylethylsilylimidazole
CAS No.	62365-34-8
Molecular Formula	C7H14N2Si
Molecular Weight	154.29 g/mol
Synonyms	1-(Dimethylethylsilyl)imidazole; DMES-Imidazole; Dimethylethylsilyl Imidazole; N-(Dimethylethylsilyl)imidazole; Ethyldimethylsilylimidazole; 1H-Imidazole, 1-[(1,1-dimethylethyl)dimethylsilyl]-; tert-Butyldimethylsilylimidazole (common misnomer, verify structure); TBDMS-Imidazole (common abbreviation, verify application)
EINECS	Contact for details

Quality Control

Our Dimethylethylsilylimidazole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC and identity confirmation by FT-IR and NMR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our commitment to cGMP principles and relevant ICH guidelines ensures the material is suitable for use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.