Description

4-Isoxazolecarbonyl Chloride, 3-Methyl- (9Ci) is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 3-methylisoxazole-4-carbonyl moiety, a privileged scaffold in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require high-purity intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole ring.
• Peptide Mimetics & PROTACs: Facilitates the creation of peptide-like structures and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Employed in the synthesis of specialized polymers and functional materials with tailored properties.
• Chemical Biology Probes: Acts as a reagent for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	4-Isoxazolecarbonyl Chloride, 3-Methyl- (9Ci)
CAS No.	62348-18-9
Molecular Formula	C5H4ClNO2
Molecular Weight	145.54 g/mol
Synonyms	3-Methylisoxazole-4-carbonyl chloride; 3-Methyl-4-isoxazolecarbonyl chloride; 4-Carbonyl chloride-3-methylisoxazole; 3-Methyl-1,2-oxazole-4-carbonyl chloride; 3-Methyl-4-isoxazolylcarbonyl chloride; 3-Methyl-4-isoxazole carboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Isoxazolecarbonyl Chloride, 3-Methyl- (9Ci) undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols include HPLC, GC, NMR, and IR spectroscopy for identity confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring full traceability and compliance with your internal quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.