Description

Isoxazole-5-Carbonyl Chloride is a versatile and highly reactive acid chloride derivative of the isoxazole heterocycle. This compound serves as a critical building block in modern organic synthesis, enabling the efficient introduction of the isoxazole-5-carbonyl moiety into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole scaffold.
• Peptide Mimetics & Bioconjugation: Facilitates the acylation of amines in amino acids or peptides to create isoxazole-containing peptidomimetics or labeled biomolecules.
• Material Science Research: Employed in the creation of specialized polymers or functional materials that incorporate heterocyclic units for specific electronic or structural properties.
• Chemical Biology Probes: Acts as a reactive handle for modifying proteins or other biological macromolecules to study function or for diagnostic purposes.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom chemical synthesis services catering to R&D and scale-up projects.

Basic Information

Product Name	Isoxazole-5-Carbonyl Chloride
CAS No.	62348-13-4
Molecular Formula	C4H2ClNO2
Molecular Weight	131.52 g/mol
Synonyms	5-Isoxazolecarbonyl chloride; Isoxazole-5-carboxylic acid chloride; 1,2-Oxazole-5-carbonyl chloride; 5-Carboxyisoxazole chloride; Isoxazol-5-ylcarbonyl chloride; 5-Chlorocarbonylisoxazole
EINECS	Contact for details

Quality Control

Our Isoxazole-5-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, amines, and strong bases. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.