Description

Orotirelin is a synthetic tripeptide analog of thyrotropin-releasing hormone (TRH). This compound is significant for its potent neuropharmacological activity and serves as a critical research tool in neuroscience and endocrinology. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and manufacturers of high-purity biochemical reagents for studying central nervous system function and developing diagnostic applications.

Application

• Neuroscience Research: Used as a potent TRH receptor agonist to study neurotransmitter release, neuronal excitability, and neuroprotection mechanisms.
• Endocrinology Studies: Employed in research investigating the hypothalamic-pituitary-thyroid axis and the regulation of thyroid-stimulating hormone (TSH).
• Pharmacological Reference Standard: Serves as a high-purity analytical standard for quality control in the production of peptide-based pharmaceuticals and research chemicals.
• Diagnostic Development: Utilized in the development and calibration of in vitro diagnostic assays for neurological and endocrine disorders.
• Biochemical Reagent: A key component in cell culture studies and signal transduction pathway analysis related to TRH activity.
• Preclinical Investigation: Supports preclinical studies exploring potential therapeutic applications for conditions like spinocerebellar degeneration and consciousness disorders.

Basic Information

Product Name	Orotirelin
CAS No.	62305-86-6
Molecular Formula	C16H22N6O4
Molecular Weight	362.39 g/mol
Synonyms	Orotirelin; YM-14673; (S)-5-Oxo-1-prolyl-L-histidyl-L-thioprolinamide; L-Pyroglutamyl-L-histidyl-L-thioproline amide; TRH analog YM 14673; Thyrotropin-releasing hormone analog; CG 3703; RGH 2202
EINECS	Contact for details

Quality Control

Our Orotirelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) documenting all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Single Maximum Impurity (HPLC)	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.