Description

7-Deazaguanosine is a modified nucleoside analog where a carbon atom replaces the nitrogen at the 7-position of the guanine base. This structural modification is crucial for its role as a key intermediate and building block in the synthesis of biologically active compounds, particularly in antiviral and anticancer research. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery. The compound's unique structure makes it valuable for probing enzyme mechanisms and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving purine metabolism and tRNA modification enzymes.
• Probe Development: Employed in the creation of molecular probes to study nucleic acid structure, function, and protein-nucleic acid interactions.
• Antiviral Agent Synthesis: A key building block for the development of compounds targeting viruses such as herpesviruses and hepatitis.
• Labeled Compound Production: Used in the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and NMR studies.
• Medicinal Chemistry: Integral to structure-activity relationship (SAR) studies aimed at optimizing the potency and selectivity of nucleoside-based drugs.

Basic Information

Product Name	7-Deazaguanosine
CAS No.	62160-23-0
Molecular Formula	C11H14N4O5
Molecular Weight	282.25 g/mol
Synonyms	7-Carbaguanosine; Tubercidin analog; Pyrrolo[2,3-d]pyrimidine nucleoside; 7-Cyano-7-deazaguanosine (precursor); 4-Amino-5-cyano-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; Queuosine precursor; 7-Deaza-Guanosine
EINECS	Contact for details

Quality Control

Our 7-Deazaguanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect stability and performance. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.