Description

n-Acetylamphotericin B Methyl Ester is a chemically modified derivative of the potent polyene macrolide antibiotic, amphotericin B. This semi-synthetic compound is valued for its role as a critical intermediate in pharmaceutical research and development, particularly in the synthesis of novel antifungal agents with potentially improved therapeutic profiles. It is primarily sought by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in antifungal drug discovery, medicinal chemistry, and the production of high-purity reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel amphotericin B analogs and prodrugs aimed at reducing toxicity while maintaining efficacy.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to understand the impact of acetylation and esterification on antifungal activity and pharmacokinetics.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating the mechanism of action of polyene antibiotics on fungal cell membranes.
• API Development: Utilized in the development and scale-up processes for new active pharmaceutical ingredients (APIs) targeting systemic fungal infections.

Basic Information

Product Name	n-Acetylamphotericin B Methyl Ester
CAS No.	62008-36-0
Molecular Formula	C49H75NO18
Molecular Weight	966.12 g/mol
Synonyms	Amphotericin B methyl ester, N-acetyl-; N-Acetylamphotericin B methyl ester; Methyl N-acetylamphotericin B; Amphotericin B methyl ester acetate; 1-(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy-19-(6-amino-6-deoxy-β-D-glucopyranosyl)oxy-15,17,21,23,25,27,29,31,33,35,37-undecahydroxy-16,28,32,38-tetramethyl-18-oxo-20-oxa-4-azaoctacyclo[27.11.2.13,7.19,13.114,18.02,26.05,10.024,39]nonatriaconta-2,5,7,9,11,13,24,26,29,31,33,35,37-tridecaene-34-carboxylic acid methyl ester acetate (ester)
EINECS	Contact for details

Quality Control

Our n-Acetylamphotericin B Methyl Ester is produced under controlled conditions to ensure high chemical purity and consistency. Each batch undergoes rigorous analytical testing, including HPLC for assay and related substance profiling, to meet stringent research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.