Description

Solutol HS 15 is a non-ionic surfactant and solubilizer derived from polyethylene glycol 660 and hydroxystearate. This versatile excipient is crucial for enhancing the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) in various formulations. It is an essential component for pharmaceutical manufacturers, formulators in the cosmetics industry, and researchers developing advanced drug delivery systems such as self-emulsifying drug delivery systems (SEDDS) and parenteral nutrition.

Application

• Primary solubilizer for lipophilic drugs in oral and injectable pharmaceutical formulations.
• Key component in the development of Self-Emulsifying Drug Delivery Systems (SEDDS) and microemulsions.
• Stabilizer and emulsifier in topical creams, ointments, and cosmetic products.
• Used in parenteral nutrition formulations as a lipid emulsion stabilizer.
• Excipient for enhancing the bioavailability of poorly soluble compounds in preclinical and clinical research.
• Wetting and dispersing agent in various industrial and agrochemical applications.

Basic Information

Product Name	Solutol HS 15
CAS No.	61909-81-7
Molecular Formula	Mixture
Molecular Weight	~960 g/mol (Average)
Synonyms	Kolliphor HS 15; Macrogol 15 Hydroxystearate; Polyoxyl 15 Hydroxystearate; PEG-15 Hydroxystearate; Solutol HS15; HS 15; Polyethylene glycol 660 hydroxystearate; 12-Hydroxyoctadecanoic acid, homopolymer, 15-ether with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)
EINECS	263-220-1

Quality Control

Our Solutol HS 15 is manufactured and tested to meet high-purity standards suitable for pharmaceutical and cosmetic applications. We provide comprehensive quality assurance, including compliance with relevant pharmacopoeial monographs where applicable. Certificates of Analysis (COA) documenting key parameters such as hydroxyl value, saponification value, acid value, and water content are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to slightly yellowish waxy solid or paste
Identification (IR)	Conforms
Hydroxyl Value	Contact for details
Saponification Value	Contact for details
Acid Value	≤ 1.0 mg KOH/g
Water Content (KF)	≤ 1.0 %
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.