Description

3-Isothiocyanatothiophene is a specialized heterocyclic building block featuring a reactive isothiocyanate group attached to a thiophene ring. This compound is valued for its role as a versatile synthon in the synthesis of complex molecules, particularly in medicinal chemistry and materials science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel thiazole and thiourea derivatives.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of biologically active molecules, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Research: Used in developing novel pesticides and herbicides by incorporating the thiophene-isothiocyanate scaffold.
• Ligand Synthesis: Serves as a building block for creating chelating ligands in coordination chemistry and catalysis.
• Polymer Modification: Employed to introduce functional groups into polymer backbones for specialty materials with tailored properties.
• Fluorescent Probe Development: Utilized in the design of thiophene-based fluorescent dyes and sensors for analytical applications.
• Cross-linking Agent: Acts as a reactive handle for bioconjugation and the cross-linking of proteins or other biomolecules in biochemical research.

Basic Information

Product Name	3-Isothiocyanatothiophene
CAS No.	61528-50-5
Molecular Formula	C5H3NS2
Molecular Weight	141.21 g/mol
Synonyms	Thiophene-3-isothiocyanate; 3-Thienyl isothiocyanate; 3-Isothiocyanatothiophene; Isothiocyanic acid 3-thienyl ester; 3-Thiophene isothiocyanate; 3-TIC; 3-Thienyl mustard oil
EINECS	Contact for details

Quality Control

Our 3-Isothiocyanatothiophene is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.