Description

Adenosine 5'-(Tetrahydrogen Triphosphate), 2'-Amino-2'-Deoxy- is a chemically modified nucleotide analog where the 2'-hydroxyl group of the ribose sugar is replaced by an amino group. This structural modification confers unique biochemical properties, making it a valuable tool for research and development in enzymology and molecular biology. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for studying ATP-dependent enzymes, synthesizing modified oligonucleotides, and developing novel therapeutic agents.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate or inhibitor to probe the active sites and catalytic mechanisms of ATP-dependent kinases, polymerases, and other nucleotide-binding enzymes.
• Oligonucleotide Synthesis: Serves as a building block for the solid-phase synthesis of modified RNA or DNA strands with enhanced stability or altered binding characteristics for therapeutic and diagnostic applications.
• Biochemical Assay Development: Employed in the development of high-throughput screening (HTS) assays to identify potential drug candidates that modulate specific enzymatic pathways.
• Structural Biology: Used in X-ray crystallography and NMR studies to determine the three-dimensional structures of protein-nucleotide complexes.
• Aptamer & SELEX Technology: Acts as a modified nucleotide pool for generating nucleic acid aptamers with improved nuclease resistance and binding affinity for target molecules.
• Labeling & Detection Probes: Can be functionalized with fluorescent or radioactive tags to create probes for tracking enzymatic activity or nucleotide incorporation in real-time.

Basic Information

Product Name	Adenosine 5'-(Tetrahydrogen Triphosphate), 2'-Amino-2'-Deoxy-
CAS No.	61468-88-0
Molecular Formula	C10H17N6O12P3
Molecular Weight	506.19 g/mol
Synonyms	2'-Amino-2'-deoxyadenosine-5'-triphosphate; 2'-NH2-dATP; 2'-Amino-dATP; 2'-Deoxy-2'-aminoadenosine triphosphate; 2'-Amino-2'-deoxy-ATP; ATP, 2'-amino-2'-deoxyadenosine-5'-; 2'-Amino-2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our Adenosine 5'-(Tetrahydrogen Triphosphate), 2'-Amino-2'-Deoxy- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, suitable for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support compliance requirements for research use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0 %
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL Test)	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.