Description

1,3-Dioxolane-4-Methanol, 2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-, trans- is a high-purity, synthetically derived chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its complex molecular architecture, featuring a dioxolane ring and an imidazole moiety, makes it a critical building block for the development of active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the production of specialized, high-value compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting fungal and other infectious diseases.
• Agrochemical Research: Serves as a precursor in the development of novel fungicides and pesticides, leveraging its dichlorophenyl and imidazole functional groups.
• Chemical Synthesis: Used in organic chemistry research for constructing complex heterocyclic frameworks and studying stereoselective reactions.
• API Development: Integral to the research and scale-up processes for new Active Pharmaceutical Ingredients requiring specific stereochemistry.

Basic Information

Product Name	1,3-Dioxolane-4-Methanol, 2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-, trans-
CAS No.	61441-65-4
Molecular Formula	C₁₄H₁₄Cl₂N₂O₃
Molecular Weight	329.18 g/mol
Synonyms	trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol; (4R)-2-[(2R)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methanol; (trans)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol; A trans enantiomer of a dioxolane-imidazole derivative; Ketoconazole intermediate; Pharmaceutical intermediate CAS 61441-65-4
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Methanol derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (trans isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.