Description

2',3'-o-(2,4,6-Trinitrophenyl) Adenosine 5'-Triphosphate Monolithium Trisodium Salt is a chemically modified nucleotide analog, specifically a trinitrophenylated ATP derivative. This compound is valued for its role as a potent inhibitor of ATP-dependent enzymes and as a critical tool in biochemical research for studying nucleotide-binding sites and energy transfer mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in enzymology, molecular biology, and metabolic pathway analysis.

Application

• Enzyme Inhibition Studies: Acts as a high-affinity, non-hydrolyzable ATP analog to investigate the kinetics and mechanisms of ATPases, kinases, and other ATP-binding proteins.
• Biochemical Research Reagent: Serves as a key substrate or inhibitor in assays designed to probe cellular energy metabolism and signal transduction pathways.
• Structural Biology: Used in X-ray crystallography and NMR studies to elucidate the three-dimensional structure of enzyme active sites by forming stable complexes.
• Diagnostic Development: Employed in the development of research-use-only (RUO) diagnostic assays for monitoring enzymatic activities related to cellular energy status.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) platforms to identify and characterize novel therapeutic compounds that target ATP-binding pockets.

Basic Information

Product Name	2',3'-o-(2,4,6-Trinitrophenyl) Adenosine 5'-Triphosphate Monolithium Trisodium Salt
CAS No.	61368-63-6
Molecular Formula	C16H15LiN8Na3O19P3
Molecular Weight	849.15 g/mol (anhydrous basis)
Synonyms	TNP-ATP (Lithium Sodium Salt); 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate; TNP-adenosine-5'-triphosphate; 1-N6-Ethenoadenosine-5'-triphosphate analog; Trinitrophenylated ATP; Adenosine-5'-triphosphate, 2',3'-O-(2,4,6-trinitrophenyl)-, monolithium trisodium salt; ATP-ε-TNP
EINECS	Contact for details

Quality Control

Our 2',3'-o-(2,4,6-Trinitrophenyl) Adenosine 5'-Triphosphate Monolithium Trisodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV absorbance)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.