Description

8-(2-Aminoethyl) Aminoadenosine-3',5'-Cyclic Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signal transduction. This compound is specifically engineered to enhance membrane permeability and stability, making it a powerful tool for modulating intracellular cAMP-dependent pathways in research. It is primarily utilized by life science researchers and pharmaceutical developers in biochemical and pharmacological studies, particularly for investigating protein kinase A (PKA) activation, gene expression regulation, and cardiac or neurological function.

Application

• Biochemical Research: As a cell-permeable cAMP analog for studying intracellular signaling cascades, PKA activation, and gene regulation.
• Pharmacology: Used in drug discovery to investigate the role of cAMP pathways in diseases and to screen for potential therapeutic agents.
• Neuroscience: Research into synaptic plasticity, neurotransmitter release, and neuronal protection mechanisms.
• Cardiovascular Research: Studies on heart muscle contractility, ion channel function, and cardioprotection.
• Cell Biology: Probing cell differentiation, proliferation, and apoptosis in various cell culture models.
• Enzyme Studies: Serving as a substrate or modulator for phosphodiesterases (PDEs) and other cAMP-metabolizing enzymes.

Basic Information

Product Name	8-(2-Aminoethyl) Aminoadenosine-3',5'-Cyclic Monophosphate
CAS No.	61363-29-9
Molecular Formula	C₁₇H₂₄N₈O₆P
Molecular Weight	476.40 g/mol
Synonyms	8-(2-Aminoethylamino)adenosine-3',5'-cyclic monophosphate; 8-AEA-cAMP; 8-(2-Aminoethylamino)-cAMP; N⁶,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate analog; 8-(2-AE) cAMP; cAMP, 8-(2-aminoethylamino)-; 8-(2-Aminoethyl)aminoadenosine cyclic 3',5'-(hydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 8-(2-Aminoethyl) Aminoadenosine-3',5'-Cyclic Monophosphate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.