Description

(R)-n-[(Phenylmethoxy)Carbonyl]-2-Pyrrolidinecarbonyl Chloride CAS NO 61350-62-7 is a high-purity chiral building block and activated ester derivative of L-proline. This compound is a critical intermediate for the synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for advanced organic synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral drugs, and other biologically active compounds.
• Peptide Chemistry: Used as an activated carboxylic acid derivative for peptide coupling reactions, facilitating the incorporation of proline derivatives into peptide chains.
• Asymmetric Synthesis: Serves as a crucial building block in the construction of complex molecules requiring high enantiomeric purity for medicinal chemistry research.
• Process Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) in pharmaceutical manufacturing.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(R)-n-[(Phenylmethoxy)Carbonyl]-2-Pyrrolidinecarbonyl Chloride
CAS No.	61350-62-7
Molecular Formula	C13H14ClNO3
Molecular Weight	267.71 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-2-pyrrolidinecarbonyl chloride; (R)-N-Cbz-Prolyl chloride; (R)-N-[(Benzyloxy)carbonyl]proline chloride; (R)-N-Carbobenzoxyprolyl chloride; (R)-1-[(Phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride; (R)-N-CBZ-Pro-Cl; L-N-Cbz-Prolyl chloride; (R)-N-[(Benzyloxy)carbonyl]-2-pyrrolidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our (R)-n-[(Phenylmethoxy)Carbonyl]-2-Pyrrolidinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.