Description

(S)-Guaifenesin CAS NO 61248-76-8 is the single enantiomer form of the widely used expectorant, offering a high-purity, stereochemically defined active pharmaceutical ingredient (API). This specific chirality is critical for targeted pharmaceutical development, where precise molecular interaction is required. It is essential for manufacturers in the pharmaceutical industry developing advanced cough suppressants, mucolytic agents, and other respiratory therapeutics that demand enantiomeric purity for optimal efficacy and regulatory compliance.

Application

• Pharmaceutical API: Primary active ingredient in enantiomerically pure cough syrups, expectorants, and cold/flu medications.
• Advanced Respiratory Therapeutics: Key component in the development of next-generation mucolytic and bronchodilator formulations.
• Chiral Intermediate: Used in the synthesis of more complex, stereospecific pharmaceutical compounds.
• Clinical Research: Reference standard and building block for pharmacological studies focusing on enantioselective activity.
• Veterinary Pharmaceuticals: Incorporated into expectorant formulations for animal health.
• Controlled-Release Formulations: Utilized in the development of sustained-action tablets and capsules for prolonged therapeutic effect.

Basic Information

Product Name	(S)-Guaifenesin
CAS No.	61248-76-8
Molecular Formula	C10H14O4
Molecular Weight	198.22 g/mol
Synonyms	(S)-3-(2-Methoxyphenoxy)-1,2-propanediol; (-)-Guaifenesin; (S)-Guaiacol glyceryl ether; Levoguaifenesin; S(-)-Guaifenesin; (S)-Glyceryl guaiacolate; (2S)-3-(2-Methoxyphenoxy)propane-1,2-diol; Guaifenesin S-enantiomer
EINECS	Contact for details

Quality Control

Our (S)-Guaifenesin is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing including chiral purity assay, identification, and impurity profiling to ensure consistent enantiomeric excess and chemical purity. Certificates of Analysis (COA) documenting compliance with agreed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is hygroscopic (moisture-sensitive); ensure containers are sealed after use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.