Description

4-Phenyl-1-Piperidineacetyl Chloride is a high-purity, reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 4-phenylpiperidine moiety, a privileged scaffold in medicinal chemistry, into target molecules via amide bond formation. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing central nervous system (CNS) active compounds, receptor modulators, and other bioactive molecules featuring the 4-phenylpiperidine pharmacophore.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the piperidine structure confers specific biological activity.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules for clients.
• Academic & Industrial R&D: Employed in research laboratories for method development, library synthesis, and exploring new chemical entities in drug discovery programs.
• Peptide Mimetic Chemistry: Facilitates the incorporation of rigid, lipophilic groups into peptide chains to create mimetics with enhanced stability and binding affinity.

Basic Information

Product Name	4-Phenyl-1-Piperidineacetyl Chloride
CAS No.	61210-02-4
Molecular Formula	C13H16ClNO
Molecular Weight	237.73 g/mol
Synonyms	1-(4-Phenylpiperidin-1-yl)ethan-1-one chloride; 4-Phenyl-1-piperidineacetic acid chloride; 2-(4-Phenyl-1-piperidinyl)acetyl chloride; 4-Phenylpiperidine-1-acetyl chloride; N-(4-Phenylpiperidin-1-yl)acetyl chloride; 1-Acetyl-4-phenylpiperidinium chloride (incorrect but common search term); α-Chloro-1-(4-phenylpiperidino)ethanone
EINECS	Contact for details

Quality Control

Our 4-Phenyl-1-Piperidineacetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not certified to a specific pharmacopeia grade, our production adheres to cGMP principles where applicable, ensuring reliable performance in critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.