Description

2',3'-Di-o-Nitro-(5'-n-Ethylcarboxamido)Adenosine is a chemically modified nucleoside derivative, serving as a critical intermediate in advanced pharmaceutical research and synthesis. Its value lies in its role as a versatile building block for developing novel adenosine receptor-targeting compounds and nucleotide analogs. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel adenosine receptor agonists and antagonists for therapeutic development.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and signaling pathways.
• Nucleoside Analog Synthesis: Serves as a starting material for creating modified nucleosides with potential antiviral or anticancer activity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug candidates targeting purinergic receptors.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2',3'-Di-o-Nitro-(5'-n-Ethylcarboxamido)Adenosine
CAS No.	61014-07-1
Molecular Formula	C13H16N8O8
Molecular Weight	412.31 g/mol
Synonyms	5'-N-Ethylcarboxamido-2',3'-di-O-nitroadenosine; 2',3'-Dinitro-NECA; NECA dinitro derivative; Adenosine, 2',3'-di-O-nitro-5'-(N-ethylcarboxamide)-; 5'-(N-Ethylcarboxamido)-2',3'-di-O-nitroadenosine; 2',3'-Di-O-nitro-5'-(N-ethylcarboxamido)adenosine; 2',3'-Dinitro-5'-N-ethylcarboxamidoadenosine
EINECS	Contact for details

Quality Control

Our 2',3'-Di-o-Nitro-(5'-n-Ethylcarboxamido)Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.