Description

2'-Amino-2'-Deoxyguanosine is a modified nucleoside analog, a key building block in nucleic acid chemistry and biochemical research. This compound is essential for the synthesis of oligonucleotides with specific functionalities, enabling advanced studies in molecular biology and drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of novel therapeutics, diagnostic probes, and genetic research tools.

Application

• Oligonucleotide Synthesis: A critical precursor for the solid-phase synthesis of modified DNA and RNA strands, introducing amino-functionalized bases.
• Antiviral & Anticancer Research: Serves as a scaffold for developing nucleoside analog prodrugs targeting viral polymerases and cellular replication mechanisms.
• Diagnostic Probe Development: Used to create labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection assays.
• Bioconjugation & Linker Chemistry: The amino group provides a handle for conjugation with fluorescent dyes, affinity tags, or drug molecules.
• Structural Biology Studies: Incorporated into nucleic acids to study structure-function relationships and protein-nucleic acid interactions.
• Synthesis of Nucleoside Libraries: A fundamental intermediate for combinatorial chemistry approaches in medicinal chemistry.

Basic Information

Product Name	2'-Amino-2'-Deoxyguanosine
CAS No.	60966-26-9
Molecular Formula	C10H14N6O4
Molecular Weight	282.26 g/mol
Synonyms	2'-Amino-2'-deoxyguanosine; 9-[(2-Amino-2-deoxy-β-D-erythro-pentofuranosyl)]guanine; 2'-Amino-dG; 2'-NH2-dG; 2′-Amino-2′-deoxyguanosine; Guanine, 9-(2-amino-2-deoxy-β-D-erythro-pentofuranosyl)-; 2'-Amino-2'-deoxy-guanosine
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification. We provide full traceability and detailed Certificates of Analysis (COA) to support your research and regulatory requirements, ensuring consistency and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.