Description

2'-Azido-D-Guanosine is a chemically modified nucleoside analog featuring an azido group at the 2' position of the ribose sugar. This compound is a critical building block and research reagent in the fields of medicinal chemistry and biochemistry. It is primarily utilized by pharmaceutical R&D teams and academic researchers for the synthesis of novel nucleotide-based therapeutics and as a probe in bioorthogonal chemistry applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside analog drugs, including potential antiviral and anticancer agents.
• Bioorthogonal Chemistry: Acts as a "click chemistry" handle due to the reactive azido group, enabling site-specific labeling and conjugation of biomolecules.
• Oligonucleotide Synthesis: Used in the research and development of modified RNA and DNA strands to study structure-activity relationships and enhance stability.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, such as those of polymerases and nucleoside kinases.
• Proteomics & Genomics: Employed in the development of probes for tracking nucleic acid metabolism and interactions within cells.
• Antiviral Research: Investigated for incorporation into nucleotide prodrugs targeting viral polymerases.

Basic Information

Product Name	2'-Azido-D-Guanosine
CAS No.	60921-30-4
Molecular Formula	C10H12N8O5
Molecular Weight	324.26 g/mol
Synonyms	2'-Azido-2'-deoxyguanosine; 2'-N3-dG; 9-[(2R,3R,4R,5R)-3-Azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 2'-azido-2'-deoxy-; 2'-Azidoguanosine; 2'-Azido-2'-deoxy-D-guanosine; 2'-Azido-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 2'-Azido-D-Guanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.