Description

n-Cbz-L-Alanyl-D-1-Aminoethylphosphonic Acid Dimethyl Ester is a sophisticated, non-natural phosphonic acid derivative designed for advanced research and synthesis. This compound is a key chiral building block, valued for its role in the development of enzyme inhibitors and biologically active molecules, particularly in the field of medicinal chemistry. It is primarily utilized by pharmaceutical R&D departments, agrochemical researchers, and specialized fine chemical manufacturers for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel drug candidates, particularly enzyme inhibitors.
• Protease Inhibitor Research: Used in the design and synthesis of transition-state analog inhibitors for various proteases due to its phosphonate moiety.
• Agrochemical Development: Serves as a building block for creating new active ingredients with specific biological targets in crop protection.
• Peptidomimetic Synthesis: Enables the construction of peptide analogs where the phosphonic acid group mimics a carboxylic acid or tetrahedral transition state.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme mechanisms and inhibition pathways.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in bioorganic and medicinal chemistry.

Basic Information

Product Name	n-Cbz-L-Alanyl-D-1-Aminoethylphosphonic Acid Dimethyl Ester
CAS No.	60668-36-2
Molecular Formula	C₁₇H₂₅N₂O₇P
Molecular Weight	400.36 g/mol
Synonyms	CBZ-L-Ala-D-AEP(O)(OMe)₂; (R)-Dimethyl 1-(((S)-1-((benzyloxy)carbonylamino)-1-oxopropan-2-yl)amino)ethylphosphonate; N-Carbobenzoxy-L-alanyl-D-1-aminoethylphosphonic Acid Dimethyl Ester; Z-L-Ala-D-AEP(O)(OMe)₂; Benzyl N-[(1S)-1-[[(1R)-1-(dimethoxyphosphoryl)ethyl]carbamoyl]ethyl]carbamate; L-Ala-D-AEP(O)(OMe)₂, N-Cbz protected; Chiral Phosphonopeptide Derivative
EINECS	Contact for details

Quality Control

Our n-Cbz-L-Alanyl-D-1-Aminoethylphosphonic Acid Dimethyl Ester is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.