Description

Etheno-2'-Deoxy-β-D-Adenosine 5'-Monophosphate CAS NO 60508-81-8 is a modified nucleoside monophosphate, specifically an etheno-bridged derivative of deoxyadenosine monophosphate. This compound is a critical biochemical tool and a key intermediate in research focused on DNA damage, mutagenesis, and the development of diagnostic probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in molecular biology, oncology research, and analytical chemistry. The product's defined structure makes it essential for studying adduct formation and developing sensitive detection methods for genetic alterations.

Application

• Biochemical Research: Used as a standard or probe in studies of DNA alkylation damage and mutagenic events.
• Analytical Reference Standard: Serves as a high-purity calibrant in HPLC, LC-MS, or other analytical methods for quantifying DNA adducts.
• Enzymology Studies: Employed as a substrate or inhibitor to investigate the activity of DNA repair enzymes and polymerases.
• Diagnostic Development: Acts as a key component in the development of immunoassays or biosensors for detecting specific DNA lesions.
• Pharmaceutical Intermediates: Utilized in the synthesis of more complex nucleotide analogs with potential therapeutic applications.
• Toxicology & Biomarker Research: Applied in research to understand exposure to certain carcinogens and to validate biomarkers of effect.

Basic Information

Product Name	Etheno-2'-Deoxy-β-D-Adenosine 5'-Monophosphate
CAS No.	60508-81-8
Molecular Formula	C₁₂H₁₄N₅O₆P
Molecular Weight	355.24 g/mol
Synonyms	1,N6-Etheno-2'-deoxyadenosine 5'-monophosphate; ε-dA 5'-Monophosphate; 1,N6-Etheno-2'-deoxyadenosine-5'-monophosphoric acid; 1,N6-Ethenodeoxyadenosine monophosphate; ε-dAMP; Etheno-dAMP; 2'-Deoxy-1,N6-ethenoadenosine 5'-monophosphate
EINECS	Contact for details

Quality Control

Our Etheno-2'-Deoxy-β-D-Adenosine 5'-Monophosphate is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure high chemical purity and structural integrity, with specifications typically meeting or exceeding research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity confirmation (by NMR/IR/MS), and impurity profile is provided with every shipment to ensure traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For extended storage under inert atmosphere, contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.