Description

1H-1,2,4-Trazole-5-Carbonyl Chloride is a versatile and highly reactive chemical building block, essential for the synthesis of complex heterocyclic compounds. Its core value lies in its ability to efficiently introduce the 1,2,4-triazole pharmacophore, a key structural motif known for imparting significant biological activity. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing the 1,2,4-triazole core, which exhibits a wide range of biological activities.
• Agrochemical Synthesis: Used in the production of novel fungicides, herbicides, and plant growth regulators where the triazole ring enhances efficacy and stability.
• Material Science Research: Serves as a precursor for creating advanced polymers, ligands for metal-organic frameworks (MOFs), and other functional materials.
• Peptide Mimetics & Bioconjugation: Employed in medicinal chemistry to create triazole-based peptide analogs or as a reactive handle for bioconjugation strategies.
• Chemical Research & Development: A fundamental reagent in organic synthesis laboratories for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	1H-1,2,4-Trazole-5-Carbonyl Chloride
CAS No.	60469-67-2
Molecular Formula	C3H2ClN3O
Molecular Weight	131.52 g/mol
Synonyms	1,2,4-Triazole-5-carbonyl chloride; 5-Carboxy-1,2,4-triazole chloride; 1H-1,2,4-Triazole-5-carboxylic acid chloride; 1,2,4-Triazole-5-carboxylic acid chloride; 5-Chlorocarbonyl-1,2,4-triazole; 1,2,4-Triazol-5-yl carbonyl chloride; 1H-1,2,4-Triazole-5-carbonyl chloride; 60469-67-2
EINECS	Contact for details

Quality Control

Our 1H-1,2,4-Trazole-5-Carbonyl Chloride is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.