Description

(3A,5B,7A,12A)-3,12-Dihydroxy-7-(Sulfooxy)-Cholan-24-Oic Acid is a sulfated bile acid derivative, a key intermediate in the synthesis of more complex bioactive compounds. Its value lies in its defined stereochemistry and functional groups, which are critical for research and development in metabolic pathways and receptor studies. This high-purity biochemical is essential for pharmaceutical R&D laboratories, academic institutions, and fine chemical manufacturers focused on hepatobiliary and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel therapeutic agents targeting bile acid receptors like FXR and TGR5.
• Biochemical Research: Used as a reference standard or substrate in studies of bile acid metabolism, transport, and signaling pathways.
• Enzymology Studies: Acts as a specific substrate for sulfatase and hydroxysteroid dehydrogenase enzymes to study enzyme kinetics and inhibition.
• Diagnostic Reagent Development: Employed in the development of diagnostic kits and assays for liver function and cholestatic diseases.
• Metabolite Standard: Provides a high-purity standard for LC-MS/MS and HPLC analysis in metabolomics and pharmacokinetic studies.
• Cell Culture & Physiology: Used in specialized cell culture media or as a tool compound to investigate the effects of sulfated bile acids on cell physiology.

Basic Information

Product Name	(3A,5B,7A,12A)-3,12-Dihydroxy-7-(Sulfooxy)-Cholan-24-Oic Acid
CAS No.	60320-05-0
Molecular Formula	C24H40O8S
Molecular Weight	488.63 g/mol
Synonyms	7-Sulfolithocholic Acid; 7-Sulfooxycholic Acid; 3α,12α-Dihydroxy-7β-sulfooxy-5β-cholan-24-oic Acid; Taurolithocholic Acid 7-Sulfate (related); Sulfated Lithocholic Acid Derivative; 7β-Sulfolithocholate; 7-O-Sulfo-Lithocholic Acid
EINECS	Contact for details

Quality Control

Every batch of (3A,5B,7A,12A)-3,12-Dihydroxy-7-(Sulfooxy)-Cholan-24-Oic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure identity, purity, and consistency for your critical research and production needs. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming compliance with in-house specifications typically including assay by HPLC, identification by spectroscopic methods, and control of related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.