Description

5-(Methoxycarbonyl)Methyl-2'-o-Methyl Uridine is a chemically modified nucleoside derivative, serving as a critical building block in advanced pharmaceutical and oligonucleotide synthesis. Its value lies in providing precise structural control for the development of therapeutic agents, including antisense oligonucleotides and mRNA-based vaccines. This high-purity intermediate is essential for research institutions and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors requiring reliable, high-quality raw materials for cutting-edge applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate specific modifications that enhance stability, specificity, and efficacy of therapeutic oligonucleotides.
• mRNA Vaccine & Therapeutic Development: Acts as a modified nucleoside triphosphate (NTP) analog for in vitro transcription to produce modified mRNA with improved translational efficiency and reduced immunogenicity.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile scaffold for the research and development of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Employed as a tool compound to study RNA structure, function, and protein-nucleic acid interactions.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for sensitive detection and analysis in molecular diagnostics.

Basic Information

Product Name	5-(Methoxycarbonyl)Methyl-2'-o-Methyl Uridine
CAS No.	60197-31-1
Molecular Formula	C13H18N2O8
Molecular Weight	330.29 g/mol
Synonyms	2'-O-Methyl-5-carboxymethyluridine; 5-Carboxymethyl-2'-O-methyluridine; 5-[(Methoxycarbonyl)methyl]-2'-O-methyluridine; 2'-O-Methyl-5-(methoxycarbonylmethyl)uridine; 5-(Methoxycarbonylmethyl)-2'-O-methyluridine; 2'-O-Me-5-CM-Uridine; 5-Carbomethoxymethyl-2'-O-methyluridine; Uridine, 5-[(methoxycarbonyl)methyl]-2'-O-methyl-
EINECS	Contact for details

Quality Control

Our 5-(Methoxycarbonyl)Methyl-2'-o-Methyl Uridine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical and biotech applications. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.