Description

O(2)'-Methyl-5-Carbamoylmethyluridine is a chemically modified nucleoside derivative, a key building block in advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a critical intermediate for the synthesis of modified oligonucleotides, enabling the study of RNA structure, function, and therapeutic potential. This high-purity compound is essential for researchers and manufacturers in the fields of antisense therapy, mRNA technology, and diagnostic probe development, where precise molecular control is paramount.

Application

• Pharmaceutical Intermediate: Critical raw material for the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block to introduce specific functionalities into synthetic RNA strands.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate RNA modification pathways and metabolism.
• Probe Development: Enables the creation of labeled nucleotides for use in diagnostic assays and genomic research tools.
• Academic & Industrial R&D: Fundamental component for exploring RNA biology, including structure-activity relationships and drug discovery platforms.

Basic Information

Product Name	O(2)'-Methyl-5-Carbamoylmethyluridine
CAS No.	60197-30-0
Molecular Formula	C12H17N3O7
Molecular Weight	315.28 g/mol
Synonyms	5-Carbamoylmethyl-2'-O-methyluridine; 2'-O-Methyl-5-carbamoylmethyluridine; 5-[(Aminocarbonyl)methyl]-2'-O-methyluridine; 2'-O-Methyl-5-(carbamoylmethyl)uridine; Uridine, 5-(carbamoylmethyl)-2'-O-methyl-; 5-CMUm; 2'-O-Me-5-CMUm
EINECS	Contact for details

Quality Control

Our O(2)'-Methyl-5-Carbamoylmethyluridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP starting material applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by HPLC, NMR, and MS. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.