Description

5-Isopropyl-2'-Deoxyuridine (Ip5Du) is a synthetic nucleoside analogue, a modified derivative of deoxyuridine featuring an isopropyl group at the 5-position of the uracil ring. This structural modification is of significant interest for its potential to modulate biological activity, particularly in the study of viral replication and nucleic acid biochemistry. It serves as a crucial building block and research tool for pharmaceutical R&D, antiviral studies, and molecular biology applications where precise nucleoside engineering is required.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Mechanism Studies: Used to investigate the structure-activity relationship (SAR) of nucleoside drugs, particularly against DNA viruses.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies involving thymidine kinase and other nucleoside-metabolizing enzymes.
• Molecular Probe Development: Acts as a precursor for labeled compounds (e.g., radiolabeled or fluorescently tagged) used in diagnostic assays and cellular tracking.
• Academic & Institutional Research: A vital reagent for universities and research institutes focusing on nucleic acid chemistry, medicinal chemistry, and drug discovery pipelines.

Basic Information

Product Name	5-Isopropyl-2'-Deoxyuridine (Ip5Du)
CAS No.	60136-25-6
Molecular Formula	C12H18N2O5
Molecular Weight	270.28 g/mol
Synonyms	Ip5Du; 5-(1-Methylethyl)-2'-deoxyuridine; 5-Isopropyl-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(propan-2-yl)pyrimidine-2,4-dione; 2'-Deoxy-5-isopropyluridine
EINECS	Contact for details

Quality Control

Our 5-Isopropyl-2'-Deoxyuridine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specification results to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.