Description

7-Deaza-2'-Deoxyadenosine is a chemically modified nucleoside analog of deoxyadenosine, where a nitrogen atom in the purine ring is replaced by a carbon atom. This structural modification is critical for its role as a key building block in oligonucleotide synthesis, particularly for creating probes and primers with enhanced stability and specific hybridization properties. It is an essential raw material for researchers and manufacturers in the fields of molecular biology, diagnostics, and pharmaceutical development.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite monomer for the solid-phase synthesis of modified DNA and RNA strands.
• Molecular Biology Research: Used in the preparation of hybridization probes, primers, and antisense oligonucleotides to study gene function and regulation.
• Diagnostic Assay Development: Incorporated into nucleic acid probes for PCR, qPCR, and microarray technologies to improve specificity and reduce background noise.
• Antiviral and Anticancer Research: Serves as a precursor in the research and development of nucleoside-based therapeutic agents.
• Biochemical Tool Development: Employed to create stable, nuclease-resistant aptamers and other functional nucleic acids.

Basic Information

Product Name	7-Deaza-2'-Deoxyadenosine
CAS No.	60129-59-1
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	7-Deaza-2'-deoxyadenosine; 7-Deaza-dA; 2'-Deoxy-7-deazaadenosine; 2'-Deoxy-7-carbaadenosine; 7-Carba-2'-deoxyadenosine; 7-Deazaadenine deoxyriboside; Tubercidin deoxyriboside analog; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 7-Deaza-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.