Description

1-Naphthyl Ester 5'-Methylthymidylic Acid is a specialized nucleotide derivative, a key building block in organic synthesis and biochemical research. This compound is valued for its role as a modified nucleoside intermediate, enabling precise structural modifications in oligonucleotide synthesis. It is primarily utilized by research institutions and pharmaceutical developers focused on nucleic acid chemistry, molecular biology, and the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: Acts as a crucial phosphoramidite or solid-phase synthesis intermediate for creating modified DNA/RNA strands.
• Biochemical Research: Used in studies investigating enzyme mechanisms, such as those involving polymerases and nucleases, where a modified thymidine substrate is required.
• Antiviral & Anticancer Agent Development: Serves as a precursor in the research and synthesis of nucleotide analog prodrugs targeting viral replication or cellular proliferation.
• Probe and Diagnostic Reagent Manufacturing: Incorporated into labeled nucleotides for use in hybridization probes, sequencing, and various diagnostic assays.
• Academic & Pharmaceutical R&D: A fundamental reagent for exploring structure-activity relationships (SAR) in medicinal chemistry programs focused on nucleoside-based therapeutics.

Basic Information

Product Name	1-Naphthyl Ester 5'-Methylthymidylic Acid
CAS No.	60091-21-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(1-Naphthyl) Thymidine 3'-Monophosphate; 1-Naphthyl Thymidine Monophosphate; 5'-Methylthymidylic Acid 1-Naphthyl Ester; Thymidine 3'-Monophosphate 1-Naphthyl Ester; 5'-O-(1-Naphthyl)-thymidine 3'-phosphate; 1-Naphthyl 5'-Methylthymidylate; dTMP 1-Naphthyl Ester; Nucleotide 1-Naphthyl Ester Derivative
EINECS	Contact for details

Quality Control

Every batch of 1-Naphthyl Ester 5'-Methylthymidylic Acid is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	Contact for details
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.